Topics of research

Within the optical molecular imaging group Groningen we aim to visualize and identify tissue and biodistribution of molecules in the near-infrared spectrum. We do this based on a clinical analytical framework enabling correlation of intraoperative fluorescence signals from a macroscopic to a microscopic level. This clinical analytical framework can be used in different parts of healthcare.

Fluorescence guided mamma surgery | OMIG
The clincial analytical framework used in our research. This allows to correlate intraoperative fluorescence signals with the histopathology from a macroscopic to a microscopic level. After a tracer injection and surgery (a-c) the surgical specimen is imaged (d-g), followed by paraffin embedding (h and i) and finally tissue slices allow microscopic correlation.
Different types of fluorescence imaging probes and their different mechanisms of action | OMIG
The different types of fluorescence imaging probes and their different mechanisms of action. (A) distribution by perfussion, (B) antibody based, (C) peptide based, (D) small molecule based, (E) activatable for example by certain secretion of tumor tissue, and (F) PH activated.