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Topics of research

Within the optical molecular imaging group Groningen we aim to visualize and identify tissue and biodistribution of molecules in the near-infrared spectrum. We do this based on a clinical analytical framework enabling correlation of intraoperative fluorescence signals from a macroscopic to a microscopic level. This clinical analytical framework can be used in different parts of healthcare.

Fluorescence guided mamma surgery | OMIG — The clincial analytical framework used in our research. This allows to correlate intraoperative fluorescence signals with the histopathology from a macroscopic to a microscopic level. After a tracer injection and surgery (a-c) the surgical specimen is imaged (d-g), followed by paraffin embedding (h and i) and finally tissue slices allow microscopic correlation.

From: Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers (2018).

Different types of fluorescence imaging probes and their different mechanisms of action | OMIG — The different types of fluorescence imaging probes and their different mechanisms of action. (A) distribution by perfussion, (B) antibody based, (C) peptide based, (D) small molecule based, (E) activatable for example by certain secretion of tumor tissue, and (F) PH activated.

From: Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review (2018).

Current Clinical Trials

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Fluorescence Molecular Endoscopy

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Molecular Fluorescence Guided Surgery

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Molecular Fluorescence Guided Oral and Maxillofacial Surgery

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Intra-Operative Pathology Assisted Surgery (IPAS)

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