Fluorescentiemicroscoo_Vision

Visualization of tissue with molecular imaging 

Using molecular targeted tracers, we enable visualization and identification of tissue and biodistribution of molecules in the near-infrared spectrum.
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OMIG logo | OMIG

OMIG

In multiple divisions we investigate the of use molecular targeted tracers for optical imaging in the near-infrared spectrum.

Fluorescence camera | OMIG

Technology

We provide in-house development of GMP tracers and develop and test multiple imaging system.

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Publications & news

Find our published research and read updates.

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Patient

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Milestones

First in-human results

In 2011 our research group performed the first in-human fluorescence study concerning intraoperative staining of ovarian cancer.

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Fluorescence guided laparoscopic surgery | OMIG

First spectroscopy study

The TRACT-I was the first study that utilized NIR spectroscopy in rectal cancer patients using Bevacizumab-IRDye800CW.

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Endoscopic spectroscopy | OMIG

First endoscopic study

In 2014 the first study started using systemic and topical administration of a fluorescence-labelled antibody against vascular endothelial growth factor (VEGF) utilizing a NIR infrared camera system.

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Topical fluorescent guided endoscopy | OMIG

First Head and Neck Cancer study

Start of ICON study; the first Head and Neck Cancer study at OMIG. The ICON study is a clinical trial for the intraoperative assessment of tumor margins during surgical treatment using cetuximab-IRDye800CW

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Start of Thyroid TARGET study

The Thyroid Cancer Target study is a dual study. The first part started in 2018, using EMI-137 in targeting thyroid cancer. The second part started in 2021, utilizing Bevacizumab-IRDye800CW.

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Thyroid Target study | OMIG

Start of first IBD study

The VISION study is the first study that focussed on IBD pathology. In this study Vedolizumab-800CW is utilized to identify inflamed gut mucosa using near-infrared fluorescence molecular endoscopy (NIR-FME), spectroscopy and confocal laser endomicroscopy (CLE).

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VISION microscopy | OMIG

Latest news & publications

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ICON in vivo NB and FMI | OMIG

New publication by De Wit et al. in Oral Oncology

• 3 min read
VISION microscopy | OMIG

Fluorescent labelled vedolizumab for real-time visualization and quantification of local drug distribution and pharmacodynamics in inflammatory bowel diseases during endoscopy (VISION)

• 4 min read
All team members
- Prof. Dr. Wouter Nagengast, Gastroenterologist
- Prof. Dr. Schelto Kruijff, Oncological and endocrine surgeon
- Dr. Pieter van der Zaag, Physicist
Light up the tissue and brighten your patient's odds.
- Prof. Dr. Max Witjes , Head and neck surgical oncologist
Portrait Wouter Nagengast | OMIG
Portrait Schelto Kruijff | OMIG
Pieter van der Zwaag | OMIG
Portrait Max Witjes | OMIG

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Recent publications

  1. Dijkstra BM, Jeltema HJR, Kruijff S, Groen RJM. The application of fluorescence techniques in meningioma surgery-a review. Neurosurg Rev. 2019 Dec;42(4):799-809. doi: 10.1007/s10143-018-01062-4. Epub 2018 Dec 6. PMID: 30519770; PMCID: PMC6821664. - Read more
  2. M. Linssen, W. Hooghiemstra, A. Jorritsma-Smit, et al. Development and characterisation of Antibody-Based Optical Imaging Probes for Inflammatory Bowel Disease. Pharmaceuticals (2021). 10.3390/ph14090922 - Read more
  3. Jaron G. de Wit, Jeroen E. van Schaik, Floris J. Voskuil, Jasper Vonk, Sebastiaan A.H.J. de Visscher, Kees-Pieter Schepman, Bernard F.A.M. van der Laan, Jan J. Doff, Bert van der Vegt, Boudewijn E.C. Plaat, Max J.H. Witjes, Comparison of narrow band and fluorescence molecular imaging to improve intraoperative tumour margin assessment in oral cancer surgery, Oral Oncology, Volume 134, 2022, https://doi.org/10.1016/j.oraloncology.2022.106099  - Read more
  4. Vonk J, de Wit JG, Voskuil FJ, Koldijk M, Rácz E, Hooghiemstra WTR, Doff JJ, Diercks GFH, van Dam GM, Witjes MJH, de Visscher SAHJ. Fluorescence molecular imaging using cetuximab-800CW in cutaneous squamous cell carcinoma surgery: a proof-of-concept study. Br J Dermatol. 2022 Jun 28. doi: 10.1111/bjd.21722 . Epub ahead of print. PMID: 35762264. - Read more
  5. Zhao X, Gabriëls RY, Hooghiemstra WTR, Koller M, Meersma GJ, Buist-Homan M, Visser L, Robinson DJ, Tenditnaya A, Gorpas D, Ntziachristos V, Karrenbeld A, Kats-Ugurlu G, Fehrmann RSN, Nagengast WB. Validation of Novel Molecular Imaging Targets Identified by Functional Genomic mRNA Profiling to Detect Dysplasia in Barrett’s Esophagus. Cancers. 2022; 14(10):2462. https://doi.org/10.3390/cancers14102462  - Read more
  6. Vonk, J. Kukačka, P.J. Steinkamp, J.G. de Wit, F.J. Voskuil, W.T.R. Hooghiemstra, M. Bader, D. Jüstel, V. Ntziachristos, G.M. van Dam, M.J.H. Witjes, "Multispectral optoacoustic tomography for in vivo detection of lymph node metastases in oral cancer patients using an EGFR-targeted contrast agent and intrinsic tissue contrast: A proof-of-concept study" Photoacoustics, 26 (2022), https://doi.org/10.1016/j.pacs.2022.100362  - Read more
  7. Vonk J, de Wit JG, Voskuil FJ, Tang YH, Hooghiemstra WT, Linssen MD, van den Broek E, Doff JJ, de Visscher SA, Schepman KP, van der Vegt B, van Dam GM, Witjes MJ. Epidermal growth factor receptor targeted fluorescence molecular imaging for postoperative lymph node assessment in patients with oral cancer. J Nucl Med. 2021 Sep 16:jnumed.121.262530. doi: 10.2967/jnumed.121.262530 - Read more
  8. Jonker, P.K.C., Metman, M.J.H., Sondorp, L.H.J. et al. Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection. Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05763-3 - Read more
  9. Iris Schmidt, Wouter B. Nagengast, Dominic J. Robinson, "Characterizing factors influencing calibration and optical property determination in quantitative reflectance spectroscopy to improve standardization," J. Biomed. Opt. 27(7) 074714 (7 April 2022) https://doi.org/10.1117/1.JBO.27.7.074714 - Read more
  10. van Heijst L, E, Zhao X, Gabriëls R, Y, Nagengast W, B: Today’s Mistakes and Tomorrow’s Wisdom in Endoscopic Imaging of Barrett’s Esophagus. Visc Med 2022. doi: 10.1159/000523907 - Read more
  11. Vergeer RA, Theunissen REP, van Elk T, Schmidt I, Postma MR, Tamasi K, van Dijk JMC, Kuijlen JMA. Fluorescence-guided detection of pituitary neuroendocrine tumor (PitNET) tissue during endoscopic transsphenoidal surgery available agents, their potential, and technical aspects. Rev Endocr Metab Disord. 2022 Mar 28. doi: 10.1007/s11154-022-09718-9. Epub ahead of print. PMID: 35344185. - Read more
  12. Feitsma EA, Schouw HM, Noltes ME, Heeman W, Kelder W, van Dam GM, Kruijff S. Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands—A Meta-Narrative Review. Life. 2022; 12(3):388. https://doi.org/10.3390/life12030388   - Read more
  14. Sterkenburg AJ, Hooghiemstra, WTR, Schmidt I, Ntziachristos V, Nagengast WB, Gorpas, D. Standardization and implementation of fluorescence molecular endoscopy in the clinic. J. of Biomedical Optics 2022; 27(7):205-212. doi.org/10.1117/1.JBO.27.7.074704 - Read more
  15. Heeman W, Vonk J, Ntziachristos V, Pogue B, Dierckx RA, Kruijff S, van Dam GM. A guideline for clinicians performing clinical studies with fluorescence imaging. J Nucl Med. 2022 Feb 10:jnumed.121.262975. doi: 10.2967/jnumed.121.262975. Epub ahead of print. PMID: 35145017. - Read more
  16. Van Manen L, Schmidt I, Inderson A, Houvast RD, Boonstra JJ, Dijkstra J, Van Hooft JE, Nagengast WB, Robinson DJ, Vahrmeijer AL, Mieog JSD. Single fiber reflectance spectroscopy for pancreatic cancer detection during endoscopic ultrasound guided fine needle biopsy: a prospective cohort study. Int J Med Sci 2022; 19(2):205-212. doi:10.7150/ijms.65364 - Read more
  17. P.J. Steinkamp, F.J. Voskuil, B. Van der Vegt, et al. A standardized framework for fluorescence-guided margin assessment for head and neck cancer using a tumor acidosis sensitive optical imaging agent, Mol imaging biol (2021), 10.1007/s11307-021-01614-z - Read more
  18. Vergeer RA, Postma MR, Schmidt I, Korsten-Meijer AG, Feijen RA, Kruijff S, Nagengast WB, van Dijk JMC, den Dunnen WFA, van Beek AP, Kuijlen JMA, van den Berg G. Detection by fluorescence of pituitary neuroendocrine tumour (PitNET) tissue during endoscopic transsphenoidal surgery using bevacizumab-800CW (DEPARTURE trial): study protocol for a non-randomised, non-blinded, single centre, feasibility and dose-finding trial. BMJ Open. 2021 Oct 7;11(10):e049109. doi: 10.1136/bmjopen-2021-049109 - Read more
  19. Noltes ME, van Dam GM, Nagengast WB, van der Zaag PJ, Slart RHJA, Szymanski W, Kruijff S, Dierckx RAJO. Let's embrace optical imaging: a growing branch on the clinical molecular imaging tree. Eur J Nucl Med Mol Imaging. 2021 Aug 31. doi: 10.1007/s00259-021-05476-z  - Read more
  20. X. Zhao, Q. Huang, M. Koller, et al. Identification and validation of esophageal squamous cell carcinoma targets for fluorescence molecular endoscopy. Int. J. Mol. Sci. (2021) 10.3390/ijms22179270 - Read more
  21. Steinkamp PJ, Vonk J, Huisman LA, Meersma GJ, Diercks GFH, Hillebrands JL, Nagengast WB, Zeebregts CJ, Slart RHJA, Boersma HH, van Dam GM. VEGF-Targeted Multispectral Optoacoustic Tomography and Fluorescence Molecular Imaging in Human Carotid Atherosclerotic Plaques. Diagnostics (Basel). 2021 Jul 7;11(7):1227. doi: 10.3390/diagnostics11071227. PMID: 34359310; PMCID: PMC8305003. - Read more
  22. Steinkamp PJ, Vonk J, Huisman LA, Meersma GJ, Diercks GFH, Hillebrands JL, Nagengast WB, Zeebregts CJ, Slart RHJA, Boersma HH, van Dam GM. VEGF-Targeted Multispectral Optoacoustic Tomography and Fluorescence Molecular Imaging in Human Carotid Atherosclerotic Plaques. Diagnostics (Basel). 2021 Jul 7;11(7):1227. https://doi.org/10.3390/diagnostics11071227 - Read more
  23. Noltes ME, Metman MJH, Heeman W, Rotstein L, van Ginhoven TM, Vriens MR, Engelsman AF, Boerma CE, Brouwers AH, van Dam GM, Pasternak JD, Kruijff S. A Novel and Generic Workflow of Indocyanine Green Perfusion Assessment Integrating Standardization and Quantification Towards Clinical Implementation. Ann Surg. 2021 Jun 10. doi: 10.1097/SLA.0000000000004978. Epub ahead of print. PMID: 34145192. - Read more
  24. Noltes ME, Metman MJH, Jansen L, Peeperkorn EWM, Engelsman AF, Kruijff S. Parathyroid Function Saving Total Thyroidectomy Using Autofluorescence and Quantified Indocyanine Green Angiography. VideoEndocrinology. 2021 Jun 10;8(2):ve.2021.0008. doi: 10.1089/ve.2021.0008. PMID: 34179223; PMCID: PMC8227798. - Read more
  25. Dijkstra BM, de Jong M, Stroet MCM, Andreae F, Dulfer SE, Everts M, Kruijff S, Nonnekens J, den Dunnen WFA, Kruyt FAE, Groen RJM. Evaluation of Ac-Lys0(IRDye800CW)Tyr3-octreotate as a novel tracer for SSTR2-targeted molecular fluorescence guided surgery in meningioma. J Neurooncol. 2021 Jun;153(2):211-222. doi: 10.1007/s11060-021-03739-1. Epub 2021 Mar 26. Erratum in: J Neurooncol. 2021 May 20;: PMID: 33768405; PMCID: PMC8211583. - Read more
  26. Steinkamp PJ, Pranger BK, Li MF, Linssen MD, Voskuil FJ, Been LB, van Leeuwen BL, Suurmeijer AJH, Nagengast WB, Kruijff S, van Ginkel RJ, van Dam GM. Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial. J Nucl Med. 2021 Mar;62(3):342-347. doi: 10.2967/jnumed.120.245696. Epub 2020 Jul 17. PMID: 32680922. - Read more
  27. J.J.H. Van der Laan, A.M. Van der Waaij, R.Y. Gabriëls, et al. Endoscopic imaging in inflammatory bowel disease: current developments and emerging strategies. Expert review of Gastroenterology and Hepatology (2021), 10.1080/17474124.2021.1840352 - Read more
  28. S.J. De Jongh, J.P.M. Vrouwe, F.J. Voskuil, et al. The optimal imaging window for dysplastic colorectal polyp detection using c-Met-targeted fluorescence molecular endoscopy.  J. Nucl. Med (2020) doi: 10.2967/jnumed.119.238790 - Read more
  29. S.J. De Jongh, J.J.J. Tjalma, M. Koller, et al. Back-table fluorescence-guided imaging for circumferential resection margin evaluation using bevacizumab-800CW in patients with locally advanced rectal cancer, J. Nucl. Med (2020) doi: 10.2967/jnumed.119.232355 - Read more
  30. de Jongh SJ, Voskuil FJ, Schmidt I, Karrenbeld A, Kats-Ugurlu G, Meersma GJ, Westerhof J, Witjes MJH, van Dam GM, Robinson DJ, Nagengast WB. C-Met targeted fluorescence molecular endoscopy in Barrett's esophagus patients and identification of outcome parameters for phase-I studies. Theranostics 2020; 10(12):5357-5367. doi:10.7150/thno.42224. - Read more
  31. J. Vonk, G. De Wit, F.J. Voskuil, M.J.H. Witjes, Improving oral cavity cancer diagnosis and treatment with fluorescence molecular imaging. Oral Diseases (2020), doi: 10.1111/odi.13308 - Read more
  32. J.J.J. Tjalma, M. Koller, M.D. Linssen, et al.  Quantitative fluorescence endoscopy: an innovative endoscopy approach to evaluate neoadjuvant treatment response in locally advanced rectal cancer. Gut (2019), doi: 10.1136/gutjnl-2019-319755 - Read more
  33. M.D. Linssen, E.J. Ter Weele, D.P Allersma, et al. Roadmap for the development and clinical translation of optical tracers cetuximab-800CW and trastuzumab-800CW J. Nucl. Med. (2019) doi: 10.2967/jnumed.118.216556 - Read more
  34. J.E.K.R. Hentzen, S.J. De Jongh, P.H.J. Hemmer, et al. Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review. J Surg Oncol. 2018 Aug;118(2):332-343. doi: 10.1002/jso.25106. Epub 2018 Jun 24. PMID: 29938400; PMCID: PMC6174973. - Read more
  35. E. Hartmans, M.D. Linssen, C. Sikkens, et al. Tyrosine kinase inhibitor induced growth factor receptor upregulation enhances the efficacy of near-infrared targeted photodynamic therapy in esophageal adenocarcinoma cell lines, Oncotarget (2017), doi: 10.18632/oncotarget.16165 - Read more
  36. N.J. Harlaar, M. Koller, S.J. De Jongh, et al. Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: a single-centre feasibility study. Lancet Gastroenterol Hepatol. 2016 Dec;1(4):283-290. doi: 10.1016/S2468-1253(16)30082-6. Epub 2016 Sep 17. PMID: 28404198. - Read more
  37. Tjalma JJ, Garcia-Allende PB, Hartmans E, Terwisscha van Scheltinga AG, Boersma-van Ek W, Glatz J, Koch M, van Herwaarden YJ, Bisseling TM, Nagtegaal ID, Timmer-Bosscha H, Koornstra JJ, Karrenbeld A, Kleibeuker JH, van Dam GM, Ntziachristos V, Nagengast WB. Molecular Fluorescence Endoscopy Targeting Vascular Endothelial Growth Factor A for Improved Colorectal Polyp Detection. J Nucl Med. 2016 Mar;57(3):480-5. doi: 10.2967/jnumed.115.166975. Epub 2015 Dec 17. PMID: 26678613. - Read more
  38. E. Hartmans, V. Orian-Rousseau, A. Matzke-Ogi, et al. Functional genomic mRNA profiling of colorectal adenomas: identification and in vivo validation of CD44 and splice variant CD44v6 as molecular imaging targets, Theranostics (2017), doi: 10.7150/thno.16816 - Read more
  39. W.B. Nagengast, E. Hartmans, P.B. Garcia-Allende, et al. Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A, Gut (2017), doi: 10.1136/gutjnl-2017-314953 - Read more
  40. E. Hartmans, J.J.J. Tjalma, M.D. Linssen, et al. Potential red-flag identification of colorectal adenomas with wide-field fluorescence molecular endoscopy, Theranostics (2018), doi: 10.7150/thno.22033 - Read more
  41. F.J. Voskuil, S.J. De Jongh, W.T.R. Hooghiemstra, et al. Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study. Theranostics (2020), doi: 10.7150/thno.43227 - Read more
  42. Vonk, J., Voskuil, F., de Wit, J. et al. Fluorescence grid analysis for the evaluation of piecemeal surgery in sinonasal inverted papilloma: a proof-of-concept study. Eur J Nucl Med Mol Imaging 49, 1640–1649 (2022). https://doi.org/10.1007/s00259-021-05567-x - Read more
  43. Schouw HM, Huisman LA, Janssen YF, Slart RHJA, Borra RJH, Willemsen ATM, Brouwers AH, van Dijl JM, Dierckx RA, van Dam GM, Szymanski W, Boersma HH, Kruijff S. Targeted optical fluorescence imaging: a meta-narrative review and future perspectives. Eur J Nucl Med Mol Imaging. 2021 Oct 11. doi: 10.1007/s00259-021-05504-y. Epub ahead of print. PMID: 34633509. - Read more