Fluorescentiemicroscoo_Vision

Visualization of tissue with molecular imaging 

Using molecular targeted tracers, we enable visualization and identification of tissue and biodistribution of molecules in the near-infrared spectrum.
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Milestones

First in-human results

In 2011 our research group performed the first in-human fluorescence study concerning intraoperative staining of ovarian cancer.

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Fluorescence guided laparoscopic surgery | OMIG

First spectroscopy study

The TRACT-I was the first study that utilized NIR spectroscopy in rectal cancer patients using Bevacizumab-IRDye800CW.

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Endoscopic spectroscopy | OMIG

First endoscopic study

In 2014 the first study started using systemic and topical administration of a fluorescence-labelled antibody against vascular endothelial growth factor (VEGF) utilizing a NIR infrared camera system.

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Topical fluorescent guided endoscopy | OMIG

First Head and Neck Cancer study

Start of ICON study; the first Head and Neck Cancer study at OMIG. The ICON study is a clinical trial for the intraoperative assessment of tumor margins during surgical treatment using cetuximab-IRDye800CW

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Start of Thyroid TARGET study

The Thyroid Cancer Target study is a dual study. The first part started in 2018, using EMI-137 in targeting thyroid cancer. The second part started in 2021, utilizing Bevacizumab-IRDye800CW.

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Thyroid Target study | OMIG

Start of first IBD study

The VISION study is the first study that focussed on IBD pathology. In this study Vedolizumab-800CW is utilized to identify inflamed gut mucosa using near-infrared fluorescence molecular endoscopy (NIR-FME), spectroscopy and confocal laser endomicroscopy (CLE).

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All team members
Light up the tissue and brighten your patient's odds.
- Prof. Dr. Max Witjes , Head and neck surgical oncologist
- Prof. Dr. Wouter Nagengast, Gastroenterologist
- Dr. Pieter van der Zaag, Physicist
- Prof. Dr. Schelto Kruijff, Oncological and endocrine surgeon
Portrait Max Witjes | OMIG
Portrait Wouter Nagengast | OMIG
Pieter van der Zwaag | OMIG
Portrait Schelto Kruijff | OMIG

We are working with...

All our partners

Recent publications

  1. Zhao X, Gabriëls RY, Hooghiemstra WTR, Koller M, Meersma GJ, Buist-Homan M, Visser L, Robinson DJ, Tenditnaya A, Gorpas D, Ntziachristos V, Karrenbeld A, Kats-Ugurlu G, Fehrmann RSN, Nagengast WB. Validation of Novel Molecular Imaging Targets Identified by Functional Genomic mRNA Profiling to Detect Dysplasia in Barrett’s Esophagus. Cancers. 2022; 14(10):2462. https://doi.org/10.3390/cancers14102462 - Read more
  2. Vonk, J. Kukačka, P.J. Steinkamp, J.G. de Wit, F.J. Voskuil, W.T.R. Hooghiemstra, M. Bader, D. Jüstel, V. Ntziachristos, G.M. van Dam, M.J.H. Witjes, "Multispectral optoacoustic tomography for in vivo detection of lymph node metastases in oral cancer patients using an EGFR-targeted contrast agent and intrinsic tissue contrast: A proof-of-concept study" Photoacoustics, 26 (2022), https://doi.org/10.1016/j.pacs.2022.100362  - Read more
  3. Jonker, P.K.C., Metman, M.J.H., Sondorp, L.H.J. et al. Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection. Eur J Nucl Med Mol Imaging (2022). https://doi.org/10.1007/s00259-022-05763-3 - Read more
  4. Iris Schmidt, Wouter B. Nagengast, Dominic J. Robinson, "Characterizing factors influencing calibration and optical property determination in quantitative reflectance spectroscopy to improve standardization," J. Biomed. Opt. 27(7) 074714 (7 April 2022) https://doi.org/10.1117/1.JBO.27.7.074714 - Read more
  5. van Heijst L, E, Zhao X, Gabriëls R, Y, Nagengast W, B: Today’s Mistakes and Tomorrow’s Wisdom in Endoscopic Imaging of Barrett’s Esophagus. Visc Med 2022. doi: 10.1159/000523907 - Read more
  6. Vergeer RA, Theunissen REP, van Elk T, Schmidt I, Postma MR, Tamasi K, van Dijk JMC, Kuijlen JMA. Fluorescence-guided detection of pituitary neuroendocrine tumor (PitNET) tissue during endoscopic transsphenoidal surgery available agents, their potential, and technical aspects. Rev Endocr Metab Disord. 2022 Mar 28. doi: 10.1007/s11154-022-09718-9. Epub ahead of print. PMID: 35344185. - Read more
  7. Feitsma EA, Schouw HM, Noltes ME, Heeman W, Kelder W, van Dam GM, Kruijff S. Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands—A Meta-Narrative Review. Life. 2022; 12(3):388. https://doi.org/10.3390/life12030388   - Read more
  8. Citation: Sterkenburg AJ, Hooghiemstra, WTR, Schmidt I, Ntziachristos V, Nagengast WB, Gorpas, D. SStandardization and implementation of fluorescence molecular endoscopy in the clinic. J. of Biomedical Optics 2022; 27(7):205-212. doi.org/10.1117/1.JBO.27.7.074704 - Read more
  9. Citation: Heeman W, Vonk J, Ntziachristos V, Pogue B, Dierckx RA, Kruijff S, van Dam GM. A guideline for clinicians performing clinical studies with fluorescence imaging. J Nucl Med. 2022 Feb 10:jnumed.121.262975. doi: 10.2967/jnumed.121.262975. Epub ahead of print. PMID: 35145017. - Read more
  10. Citation: Van Manen L, Schmidt I, Inderson A, Houvast RD, Boonstra JJ, Dijkstra J, Van Hooft JE, Nagengast WB, Robinson DJ, Vahrmeijer AL, Mieog JSD. Single fiber reflectance spectroscopy for pancreatic cancer detection during endoscopic ultrasound guided fine needle biopsy: a prospective cohort study. Int J Med Sci 2022; 19(2):205-212. doi:10.7150/ijms.6536 - Read more
  11. Citation: E. Hartmans, M.D. Linssen, C. Sikkens, et al. Tyrosine kinase inhibitor induced growth factor receptor upregulation enhances the efficacy of near-infrared targeted photodynamic therapy in esophageal adenocarcinoma cell lines, Oncotarget (2017), 10.18632/oncotarget.16165 - Read more
  12. N.J. Harlaar, M. Koller, S.J. De Jongh, et al. Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: a single-centre feasibility study. Lancet Gastroenterol Hepatol. 2016 Dec;1(4):283-290. doi: 10.1016/S2468-1253(16)30082-6. Epub 2016 Sep 17. PMID: 28404198. - Read more
  13. J.J.J. Tjalma, P. Beatriz Garcia-Allende, E. Hartmans, et al. Molecular fluorescence endoscopy targeting vascular endothelial growth factor a for improved colorectal polyp detection, J. Nucl. Med. (2016), 10.2967/jnumed.115.166975     Anton G. Terwisscha van ScheltingaWytske Boersma-van EkJürgen GlatzMaximilian KochYasmijn J. van HerwaardenTanya M. BisselingIris D. NagtegaalHetty Timmer-BosschaJan Jacob KoornstraArend KarrenbeldJan H. KleibeukerGooitzen M. van DamVasilis Ntziachristos and Wouter B. Nagengast - Read more
  14. Vonk J, de Wit JG, Voskuil FJ, Koldijk M, Rácz E, Hooghiemstra WTR, Doff JJ, Diercks GFH, van Dam GM, Witjes MJH, de Visscher SAHJ. Fluorescence molecular imaging using cetuximab-800CW in cutaneous squamous cell carcinoma surgery: a proof-of-concept study. Br J Dermatol. 2022 Jun 28. doi: 10.1111/bjd.21722. Epub ahead of print. PMID: 35762264. - Read more
  15. E. Hartmans, V. Orian-Rousseau, A. Matzke-Ogi, et al. Functional genomic mRNA profiling of colorectal adenomas: identification and in vivo validation of CD44 and splice variant CD44v6 as molecular imaging targets, Theranostics (2017), 10.7150/thno.16816 - Read more
  16. W.B. Nagengast, E. Hartmans, P.B. Garcia-Allende, et al. Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A, Gut (2017), 10.1136/gutjnl-2017-314953 - Read more