Current Clinical Trials
Multiple clinical trials are ongoing in the Optical Molecular Imaging Group. The overview below shows which trials are currently running and their status.
COUGAR – Jouke van der Laan and Boudewijn de Vries
Perihilar cholangiocarcinoma detection using an intraoperative and endoscopic fluorescence guided approach using Bevacizumab-800CW.
Started July 2018. Currently enrolling patients.
ORCA – Iris Schmidt and Anne van der Waaij
Fluorescence molecular endoscopy for response monitoring of esophageal cancer patients after neoadjuvant chemoradiotherapy using bevacizumab-800CW.
Started November 2018, currently enrolling patients.
ESCEND – Ruben Gabriëls and Wouter Hooghiemstra
Phase II near-infrared fluorescent endoscopy in combination with Bevacuzimab-IRDye800CW to visualize HD white light invisible dysplastic esophageal lesions.
Started July 2019. Last patient in April 2022.
VISION – Ruben Gabriëls and Anne van der Waaij
Phase I feasibility study investigating vedoluzimab distribution and detection vedoluzimab target cells in patient with inflammatory bowel disease.
Started January 2020. Last patient in April 2022.
TRACT-II – Anne van der Waaij and Wouter Hooghiemstra
Visualization of treatment response using cetuximab-800CW during fluorescence endoscopy in rectal cancer.
Started November 2020. Last patient in January 2022.
DEPARTURE – Iris Schmidt
The DEPARTURE study evaluates the feasibility of using intraoperative fluorescence imaging for the detection of bevacizumab-800CW accumulation in pituitary neuroendocrine tumor tissue.
Started November 2020, currently enrolling patients.
Pre-CLOVER – Eline Feitsma
Utilizing Indocyanine Green (ICG) during total thyroidectomy for the purpose of parathyroid gland identification and preservation by means of fluorescence-guided surgery.
Started November 2020, currently enrolling patients.
DEFENCE – Sara Hone-Lopez and Andrea Sterkenburg
Studying the gut immune system and its changes during immunotherapy to understand the determinants of immunotherapy respons.
Started November 2021, currently enrolling patients.
TARGET-Beva – Eline Feitsma
Margin and metastatic lymph node detection in patients with thyroid carcinoma, utilizing the fluorescent tracer Bevacizumab-IRDye800CW and the Quest Platform Camera system for in vivo imaging.
Started December 2021, currently enrolling patients.
GLANS – Thom Nijboer
Visualization and resection margin assessment of penile carcinoma using the fluorescent tracer cetuximab-800CW and Surgvision camera system.
Started March 2022, currently enrolling patients.
SELECT – Femke van der Zant and Eline Feitsma
Detection of tumor tissue in peritoneal metastases of colorectal origin using Bevacizumab-IRDye800CW during diagnostic laparoscopy
Started May 2022, currently enrolling patients.
LUMINA – Bianca Dijkstra
