Current Clinical Trials

Multiple clinical trials are ongoing in the Optical Molecular Imaging Group. The overview below shows which trials are currently running and their status.

In the coming period, blogs will be written about the ongoing clinical studies. These blogs will be linked in the study title below.

COUGAR – Jouke van der Laan and Boudewijn de Vries

Perihilar cholangiocarcinoma detection using an intraoperative and endoscopic fluorescence guided approach using Bevacizumab-800CW.

Started July 2018. Currently enrolling patients.

 

ORCA – Iris Schmidt and Anne van der Waaij

Fluorescence molecular endoscopy for response monitoring of esophageal cancer patients after neoadjuvant chemoradiotherapy using bevacizumab-800CW.

Started November 2018, currently enrolling patients.

 

ESCEND – Ruben Gabriëls and Wouter Hooghiemstra

Phase II near-infrared fluorescent endoscopy in combination with Bevacuzimab-IRDye800CW to visualize HD white light invisible dysplastic esophageal lesions.

Started July 2019. Last patient in April 2022.

 

VISION – Ruben Gabriëls and Anne van der Waaij

Phase I feasibility study investigating vedoluzimab distribution and detection vedoluzimab target cells in patient with inflammatory bowel disease.

Started January 2020. Last patient in April 2022.

 

TRACT-II – Anne van der Waaij and Wouter Hooghiemstra

Visualization of treatment response using cetuximab-800CW during fluorescence endoscopy in rectal cancer.

Started November 2020. Last patient in January 2022.

 

DEPARTURE – Iris Schmidt

The DEPARTURE study evaluates the feasibility of using intraoperative fluorescence imaging for the detection of bevacizumab-800CW accumulation in pituitary neuroendocrine tumor tissue.

Started November 2020, currently enrolling patients.

 

Pre-CLOVEREline Feitsma

Utilizing Indocyanine Green (ICG) during total thyroidectomy for the purpose of parathyroid gland identification and preservation by means of fluorescence-guided surgery.

Started November 2020, currently enrolling patients.

 

DEFENCESara Hone-Lopez and Andrea Sterkenburg

Studying the gut immune system and its changes during immunotherapy to understand the determinants of immunotherapy respons.

Started November 2021, currently enrolling patients.

 

TARGET-Beva – Eline Feitsma

Margin and metastatic lymph node detection in patients with thyroid carcinoma, utilizing the fluorescent tracer Bevacizumab-IRDye800CW and the Quest Platform Camera system for in vivo imaging.

Started December 2021, currently enrolling patients.

 

GLANS – Thom Nijboer

Visualization and resection margin assessment of penile carcinoma using the fluorescent tracer cetuximab-800CW and Surgvision camera system.

Started March 2022, currently enrolling patients.

 

SELECT – Femke van der Zant and Eline Feitsma

Detection of tumor tissue in peritoneal metastases of colorectal origin using Bevacizumab-IRDye800CW during diagnostic laparoscopy

Started May 2022, currently enrolling patients.

 

LUMINA – Bianca Dijkstra

ESCEND lesion esophagus | OMIG