Upcoming: PhD defense Matthijs Linssen


Matthijs Linssen will defend his PhD on the 8th of February at 16:15, at the academybuilding of the University of Groningen. The title of his thesis is: “Fluorescently labelled monoclonal antibodies for real-time molecular imaging”. The online defense can be followed via this link.


This thesis discusses the pharmaceutical development path of fluorophore-conjugated monoclonal antibodies from lab-scale experiments to investigational medicinal products for clinical trials, and the clinical translation required to reach this point. The thesis also shows the imaging results of applying the optimized tracers in clinical trials for surgery as well as endoscopy. The final part of the thesis shows steps to expand the scope of tracer development to new types of antibodies: anti-cancer immunotherapy monoclonal antibodies and biologicals licensed for the treatment of inflammatory bowel disease.